FACULTATIVE CANCER MANAGEMENT ANAEROBE SALMONELLA: A PREFERENTIAL CHOICE FOR
Abstract
Abstract
The hypoxic microenvironment of tumor tissue provides a conducive environment for the growth of facultative and anaerobic bacteria. Researchers have exploited this property of bacteria for the clinical management of cancer. Among the different bacteria, Salmonella is the most preferred choice due to its genetic manipulability. In this article, we discuss the mechanism of Salmonella-host interaction and the ways in which this bacterium can be used for cancer treatment. Salmonella can be genetically engineered to deliver anticancer agents or act as a therapeutic for cancer treatment. The ability of Salmonella to grow in the hypoxic microenvironment and its chemotaxis ability make it a promising candidate for anticancer therapy. However, Salmonella-based drug delivery also has its challenges, and future work needs to focus on enhancing its target-specificity and patient-safety abilities for its successful use in cancer treatment. Several types of cancer, including pancreatic, prostate, breast, spinal-cord cancers, and some tumor metastases, have been successfully treated by S. typhimurium, making it a potential candidate for cancer therapy in the future
