STEROID SIDE CHAIN MODIFICATION AT A DISTANCE: CHROMIC ANHYDRIDES IN ACTION

Abstract

Natural steroids feature diverse side chains in terms of their structure and composition, presenting unique challenges for organic chemists [3-6]. The modification of existing side chains, even those containing unsaturation, is relatively straightforward compared to the intricate and time-consuming process of constructing new side chains. Many naturally occurring steroids possess saturated side chains devoid of useful functionalities, complicating the chemist's task [1,2]. This study focuses on the intricate field of functionalizing saturated side chains in steroids, with a particular emphasis on cholesterol. Through rigorous chemical synthesis techniques, we aim to address the complexities surrounding this problem and contribute to a deeper understanding of steroid chemistry. Our research seeks to provide valuable insights into the synthesis of functionalized steroids, opening new avenues for drug development, biochemistry, and the pharmaceutical industry.