MAPPING THE LANDSCAPE OF RESEARCH ON DISC DEGENERATION AND DEGENERATIVE DISC DISEASE
Abstract
Intervertebral disc degenerative diseases have been increasingly explored, focusing on the balance of synthesis and catabolism, extracellular matrix, growth factors, and inflammatory factors as the underlying causes. Researchers have sought to address these conditions through molecular therapy, cell therapy, and gene therapy. While molecular therapy targets the regulation of growth factors and reduction of inflammatory factors, cell therapy involves the transplantation of exogenous cells and autologous nucleus pulposus cells. Gene therapy, on the other hand, is focused on the inhibition of inflammatory factors through exogenous growth factors. However, these biotherapies face challenges due to the incomplete understanding of disc degeneration's pathogenesis. Advancements in biological therapy depend on further elucidating the mechanisms of intervertebral disc degeneration, making it a crucial area for research exploration.
In this study, we conduct a bibliometric analysis to assess the current status and trends in intervertebral disc degeneration research, with a particular focus on nucleus pulposus cells and inflammatory responses. The aim is to identify promising keywords and research directions in this field.
Keywords:
Intervertebral disc degeneration, Nucleus pulposus cells, inflammatory responses, Molecular therapy, Bibliometric analysisDownloads
Published
Issue
Section
How to Cite
License
Copyright (c) 2023 Dr. Xue Mei Wang, Zhijie Li

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Kirnaz S, Capadona C, Wong T, et al. Fundamentals of Intervertebral Disc Degeneration. World Neurosurgery. 2022; 157:264-273. doi:10. 1016/j. wneu. 2021. 09. 066
Kamali A, Ziadlou R, Lang G, et al. Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions. Theranostics. 2021; 11(1):27-47. doi:10. 7150/thno. 48987
Ohnishi T, Iwasaki N, Sudo H. Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review. Cells. 2022; 11(3):394. doi:10. 3390/cells11030394
Zhang G, Liu M, Chen H, et al. NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif. 2021; 54(7). doi:10. 1111/cpr. 13057
Liao Z, Li S, Lu S, et al. Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration. Biomaterials. 2021; 274:120850. doi:10. 1016/j. biomaterials. 2021. 120850
Cazzanelli P, Wuertz-Kozak K. MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. IJMS. 2020; 21( 10):3601. doi:10. 3390/ijms21103601
Fisher JN, Tessaro I, Bertocco T, Peretti GM, Mangiavini L. The Application of Stem Cells from Different Tissues to Cartilage Repair. Stem Cells International. 2017;2017:1- 14. doi:10. 1155/ 2017/ 2761678
Xing D, Kwong J, Yang Z, et al. Intra-articular injection of mesenchymal stem cells in treating knee osteoarthritis: a systematic review of animal studies. Osteoarthritis and Cartilage. 2018; 26(4): 445461. doi:10. 1016/j. joca. 2018. 01. 010
Brandt JS, Hadaya O, Schuster M, Rosen T, Sauer MV, Ananth CV. A Bibliometric Analysis of TopCited Journal Articles in Obstetrics and Gynecology. JAMA Netw Open. 2019;2( 12):e1918007. doi: 10. 1001/jamanetworkopen. 2019. 18007
Schober P, Vetter TR. Logistic Regression in Medical Research. Anesthesia & Analgesia. 2021; 132(2): 365-366. doi:10. 1213/ANE. 0000000000005247
Synnestvedt MB, Chen C, Holmes JH. CiteSpace II: visualization and knowledge discovery in bibliographic databases. AMIA Annu Symp Proc. 2005; 2005:724-728.
Christodoulou E, Ma J, Collins GS, Steyerberg EW, Verbakel JY, Van Calster B. A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models. Journal of Clinical Epidemiology. 2019;110:12-22. doi:10. 1016/ j. jclinepi. 2019. 02. 004
Zhang Y, Han S, Kong M, Tu Q, Zhang L, Ma X. Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration. Osteoarthritis and Cartilage. 2021; 29(9):1324- 1334. doi:10. 1016/j. joca. 2021. 06. 010
Vergroesen PPA, Kingma I, Emanuel KS, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis and Cartilage. 2015;23(7):1057- 1070. doi:10. 1016/ j. joca. 2015. 03. 028
Lindbäck Y, Tropp H, Enthoven P, Abbott A, Öberg B. PREPARE: presurgery physiotherapy for patients with degenerative lumbar spine disorder: a randomized controlled trial. The Spine Journal. 2018; 18(8):1347- 1355. doi:10. 1016/j. spinee. 2017. 12. 009
Yurube T, Buchser WJ, Moon HJ, et al. Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study. Eur Spine J. 2019; 28(5):993- 1004. doi:10. 1007/s00586-019-05910-9
Pfirrmann CWA, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration: Spine. 2001; 26( 17):1873- 1878. doi:10. 1097/00007632-200109010-00011
Adams MA, Roughley PJ. What is Intervertebral Disc Degeneration, and What Causes It?: Spine. 2006; 31( 18):2151-2161. doi:10. 1097/01. brs. 0000231761. 73859. 2c
Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol. 2014;10( 1):44-56. doi:10. 1038/nrrheum. 2013. 160
Le Maitre C, Freemont AJ, Hoyland J. The role of interleukin- 1 in the pathogenesis of human Intervertebral disc degeneration. Arthritis Res Ther. 2005;7(4):R732. doi:10. 1186/ar1732
Buckwalter JA. Aging and Degeneration of the Human Intervertebral Disc: Spine. 1995;20( 11):1307- 1314. doi:10. 1097/00007632- 199506000-00022
Chu P, Wang T, Zheng J, et al. Global and Current Research Trends of Unilateral Biportal Endoscopy/Biportal Endoscopic Spinal Surgery in the Treatment of Lumbar Degenerative Diseases: A Bibliometric and Visualization Study. Orthopaedic Surgery. 2022;14(4):635-643. doi:10. 1111/os. 13216
He Y, Li M, Yu H, et al. Bibliometric and altmetric analysis of research relating to antiphospholipid syndrome based on VOS viewer (2011–2021). Clin Rheumatol. Published online January 5, 2023. doi:10. 1007/s10067-022-06485-5
Kirnaz S, Capadona C, Wong T, et al. Fundamentals of Intervertebral Disc Degeneration. World Neurosurgery. 2022; 157:264-273. doi:10. 1016/j. wneu. 2021. 09. 066
Mern DS, Walsen T, Beierfuß A, Thomé C. Animal models of regenerative medicine for biological treatment approaches of degenerative disc diseases. Exp Biol Med (Maywood). 2021; 246(4): 483-512. doi:10. 1177/ 1535370220969123
Zhai X, Wang Q, Li M. Tu Youyou’s Nobel Prize and the academic evaluation system in China. The Lancet. 2016; 387(10029):1722. doi:10. 1016/S0140-6736( 16)30261-6
Tekari A, Marazza A, Crump K, Bermudez‐Lekerika P, Gantenbein B. Inhibition of the extracellular signal‐regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells. Journal Orthopaedic Research. 2022;40( 10):2362-2371. doi:10. 1002/jor. 25273
Du K, He X, Deng J. MicroRNA- 16 inhibits the lipopolysaccharide-induced inflammatory response in nucleus pulposus cells of the intervertebral disc by targeting TAB3. Arch Med Sci. 2021; 17(2):500-513. doi:10. 5114/aoms. 2018. 74950
She Y, Tang S, Zhu Z, et al. Comparison of temporomandibular joint disc, meniscus, and intervertebral disc in fundamental characteristics and tissue engineering. J Biomed Mater Res. 2023; 111(3):717-729. doi:10. 1002/jbm. b. 35178
Gkantsinikoudis N, Kapetanakis S, Magras I, Tsiridis E, Kritis A. Tissue Engineering of Human Intervertebral Disc: A Concise Review. Tissue Engineering Part B: Reviews. 2022; 28(4): 848-860. doi:10. 1089/ten. teb. 2021. 0090