UV SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL IN COMBINATION WITH DIFFERENT DRUGS

Abstract

The use of multi-component formulations is essential in the pharmaceutical industry for enhanced efficacy, higher patient acceptance, minimal side effects, and faster relief. Paracetamol is a widely used non-steroidal anti-inflammatory drug with antipyretic and analgesic actions that is available in various combinations. The simultaneous estimation of paracetamol with different drugs is crucial for the quantitative evaluation of such multi-component formulations. Absorption spectroscopy, particularly UV spectrophotometry, is a preferred tool for quantitative analysis due to its simplicity, sensitivity, and cost-effectiveness. This review focuses on the simultaneous estimation of paracetamol with drugs like Domperidone, Aceclofenac, Diclofenac Sodium, Etodolac, Ibuprofen, Piroxicam, Caffeine, Aspirin, and their combinations using various UV spectrophotometric methods, including the simultaneous equation method, absorbance ratio (QAnalysis), difference spectrophotometry, derivative spectroscopy method, and other chemometric methods. The review provides an exhaustive literature on the methods used for the estimation of paracetamol with different drugs, which would aid researchers and scholars working in this area.