American Journal of Public Health and Epidemiology (AJPHE)

HEPATOPROTECTIVE EFFECT OF HARUNGANA MADAGASCARIENSIS AGAINST SUBCHRONIC 2,2-DICHLOROVINYL DIMETHYL PHOSPHATE (DDVP) INDUCED TOXICITY IN MALE WISTAR ALBINO RATS.

Authors

  • Igboekwe Chukwunonso Onyedika World bank African Center for Excellence in Public Health and Toxicological Research (ACE-PUTOR), University of Port-Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria.
  • Onyeike Eugene Nwaogwugwu Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, Rivers State, Nigeria
  • Patrick-Iwuanyanwu Kingsley Chukwuemeka Center for Marine Pollution Monitoring and Seafood Safety (CEMPOS) University of Port-Harcourt, Rivers State, Nigeria
  • Ikewuchi Catherine Chidinma Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, Rivers State, Nigeria
  • Igboekwe Dumfechi Chekwube. Business School, Ahmadu Bello University (ABU), Kaduna State, Nigeria

Abstract

This study investigated the hepatoprotective potential of Harungana madagascariensis (HM) extract against sub chronic toxicity induced by 2,2-dichlorovinyl dimethyl phosphate (DDVP) in Wistar albino rats. Wistar albino rats were randomly assigned to five groups of Eight (8) rats each; control (group 1), ‘DDVP exposed’ alone (group 2), and treatment groups (groups 3, 4, 5 ‘DDVP exposed’ + 50 mg/kg, 100 mg/kg, 150 mg/kg H. madagascariensis extract, respectively). The study spanned for 30 days, during which the male rats were treated with DDVP (10 mg/kg b.w) except for the positive control while organ weights (liver, kidney, heart, testes/epididymis), serum liver enzyme biomarkers (ALP, AST, ALT, total bilirubin, total protein), and percentage weight gain were assessed at the end of the study. The negative control group exhibited significant reductions in organ weights, elevated liver enzyme biomarkers, and decreased weight gain, indicative of DDVP-induced hepatotoxicity. The treatment groups demonstrated varying degrees of recovery in organ weights and serum biomarkers, with higher doses of HM extract showing more pronounced effects. H. madagascariensis extract exhibited hepatoprotective potential against sub-chronic DDVP-induced toxicity, as evidenced by improvements in organ weights, serum biomarkers, and weight gain. The observed dose-dependent responses highlighted the significance of HM as a potential therapeutic agent in achieving optimal hepatoprotection. These findings contribute to the understanding of natural remedies like plant-based supplements for control of pesticide-induced toxicity with HM having suggestive evidence of therapeutic potential for treatment of liver-related disorders.

Keywords:

Hepatoprotective, Harungana madagascariensis, toxicity, 2,2-dichlorovinyl dimethyl phosphate, Therapeutic.

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Published

2024-05-01

DOI:

https://doi.org/10.5281/zenodo.11097192

Issue

Vol. 10 No. 2 (2024): March-April

Section

Articles

How to Cite

Igboekwe , C. O., Onyeike , E. N., Patrick-Iwuanyanwu, K. C., Ikewuchi, C. C., & Igboekwe , D. C. (2024). HEPATOPROTECTIVE EFFECT OF HARUNGANA MADAGASCARIENSIS AGAINST SUBCHRONIC 2,2-DICHLOROVINYL DIMETHYL PHOSPHATE (DDVP) INDUCED TOXICITY IN MALE WISTAR ALBINO RATS. American Journal of Public Health and Epidemiology (AJPHE), 10(2), 1–10. https://doi.org/10.5281/zenodo.11097192

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Copyright (c) 2024 Igboekwe Chukwunonso Onyedika, Onyeike Eugene Nwaogwugwu, Patrick-Iwuanyanwu Kingsley Chukwuemeka, Ikewuchi Catherine Chidinma, Igboekwe Dumfechi Chekwube.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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