International Journal of Artificial Intelligence, Machine Learning and Data Science (IJAIMLDS)

INVESTIGATING PROMETHAZINE'S ANTIDOTAL ROLE IN DICHLORVOS POISONING

Authors

  • Dr. Olumide Akinwande Ogunlade Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria

Abstract

Dichlorvos, an organophosphate insecticide, is widely utilized to combat household and stored product insects. Its efficacy extends to a range of pests in greenhouse and outdoor fruit and vegetable crops. The mode of action involves the inhibition of synaptic acetylcholinesterase, which also accounts for its toxicity. Tragically, dichlorvos pesticide self-poisoning constitutes a significant clinical challenge in the developing world, resulting in approximately 200,000 fatalities annually. Organophosphate poisoning, with dichlorvos as a notable contributor, poses a pressing concern in Nigeria, given its prevalent use by farmers and households for pest control. In this context, we conducted a research study to investigate the potential antidotal effects of promethazine, a first-generation antihistamine and neuroleptic medication, in cases of dichlorvos poisoning in rats.

Keywords:

Dichlorvos, Organophosphate Poisoning, Promethazine, Antidotal Effect, Rat Model Study

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Published

2023-11-02

Issue

Vol. 6 No. 3 (2022): July-September

Section

Articles

How to Cite

Ogunlade, O. A. (2023). INVESTIGATING PROMETHAZINE’S ANTIDOTAL ROLE IN DICHLORVOS POISONING. International Journal of Artificial Intelligence, Machine Learning and Data Science (IJAIMLDS), 6(3), 1–6. Retrieved from https://zapjournals.com/Journals/index.php/ijaimlds/article/view/1494