EFFECT OF BRYOPHYLLUM PINNATUM ON LIVER ENZYME FUNCTION IN MALE WISTAR ALBINO RATS EXPOSED TO MIXED PETROLEUM PRODUCTS
Abstract
Exposure to petroleum product mixtures can harm the liver, leading to changes in liver enzyme levels. This study aimed to investigate the effects of Bryophyllum pinnatum extracts on liver enzyme function in male Wistar albino rats exposed to mixed petroleum products. The study involved 25 male Wistar albino rats randomly divided into 5 groups (the blank control, negative control, low-, medium-, and high-dose extract treatment groups). The extracts significantly reduced (p > 0.05) elevated liver enzyme levels in rats exposed to petroleum product mixtures, indicating a protective effect. The AST levels showed a significant difference (p<0.05) between the negative control (35.32 ± 0.03 and the low-dose extracts (37.40 ± 0.10) compared with the blank control. This showed that mixed petroleum product fumes increased the AST level of the experimental rats. These findings suggest that B. pinnatum extracts may be useful in mitigating the harmful effects of petroleum product mixtures on the liver. Based on this study’s findings, several recommendations can be proposed for future research and clinical practice. Further investigations are warranted to elucidate the specific mechanisms by which petroleum products increase liver enzyme levels. Understanding these pathways could lead to the development of targeted therapeutic interventions to mitigate liver damage.
Keywords:
Petroleum products, AST, ALT, ALP, GGTDownloads
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Copyright (c) 2025 Edoga Cyril Onyekachi, Sowunmi Kehinde Olukemi , Nnamani Chidinma praise
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