Global Journal of Medical and Health Science

EFFECTS OF Bryophyllum pinnatum EXTRACTS ON LIVER ENZYME FUNCTION IN MALE WISTAR ALBINO RATS EXPOSED TO PREMIUM MOTOR SPIRIT (PMS)

Authors

  • Edoga Cyril Onyekachi Department of Applied Biology and Biotechnology, Faculty of Biological Sciences, Enugu State University of Science and Technology (ESUT)
  • Sowunmi Kehinde Olukemi Department of Applied Biology and Biotechnology, Faculty of Biological Sciences, Enugu State University of Science and Technology (ESUT)
  • Okoh Emmanuel Chidera Department of Applied Biology and Biotechnology, Faculty of Biological Sciences, Enugu State University of Science and Technology (ESUT)

Abstract

Exposure to Premium Motor Spirit (PMS) can cause hepatotoxicity, which is typified by changes in liver enzyme levels. In this work, male wistar albino rats subjected to PMS were used to examine the hepatoprotective effects of Bryophyllum pinnatum extracts on liver enzyme activity. Five (5) groups of rats were created: low-dose extract, medium-dose extract, high-dose extract, blank control, and negative control. Every group—aside from the blank control group—was subjected to PMS inhalation. Following a 28-day experiment, liver enzyme activity (ALT, AST, ALP, and GGT) were measured. Exposure to PMS markedly elevated liver enzyme activity, suggesting hepatotoxicity. Hepatoprotection was suggested by the considerable reduction in liver enzyme activity following treatment with Bryophyllum pinnatum extract. Compared with the blank control (30.48 ± 0.01) in week 2, the results indicated a dosage-dependent decrease in AST enzyme activity, with the highest dose (29.85 ± 0.12) showing the most significant reduction (p>0.05), followed by the medium-dose at (31.74 ± 0.32). At week 4, the outcomes showed the same trend. These results suggest that Bryophyllum pinnatum extracts can be used as a medicinal agent because they can lessen PMS-induced hepatotoxicity

Keywords:

PMS, Bryophyllum Pinnatum, ALT, AST, ALP, GGT

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Published

2025-05-26

DOI:

https://doi.org/10.5281/zenodo.15520078

Issue

Vol. 12 No. 2 (2025): April-June

Section

Articles

How to Cite

Edoga, C. O., Olukemi , S. K., & Okoh, E. C. (2025). EFFECTS OF Bryophyllum pinnatum EXTRACTS ON LIVER ENZYME FUNCTION IN MALE WISTAR ALBINO RATS EXPOSED TO PREMIUM MOTOR SPIRIT (PMS). Global Journal of Medical and Health Science, 12(2), 8–16. https://doi.org/10.5281/zenodo.15520078

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Copyright (c) 2025 Edoga Cyril Onyekachi, Sowunmi Kehinde Olukemi , Okoh Emmanuel Chidera

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

References

Afolabi, O. K., Aderibigbe, F. A., & Folarin, D. T. (2018). Oxidative stress and subsequent sub-lethal oral exposure of cypermethrin in rats: mitigating potential of epicatechin. Toxicology Reports, 5:637–643.

Abdel-Baset, H., Omar, E., Samar, H.A., Fathy, A.G. Y. and Hafez A. (2017). The biochemical effects of antioxidants on lipids and liver function in experimentally induced liver damage. Annal of Clinical Biochemistry 34:656-663.

Adedeji, A. L., Oyewopo, A. O., and Oyeleke, S. B. (2020). Hepatoprotective effects of Bryophyllum pinnatum against premium motor spirit-induced liver damage in rats. Journal of Ethnopharmacology, 256:112414.

Anaga, Aruh & Onehi, E. (2010). Antinociceptive and anti-inflammatory effects of the methanol seed extract of Carica papaya in mice and rats. African Journal of Pharmacy and Pharmacology. 4:140-144.

Ezejindu, D.N., Chinweife, K. C., and Ihentuge, C.J. (2016). Effects of Moringa Extract Liver Enzymes of Carbon Tetrachloride-induced Hepatotoxicity in Adult Wistar

Rats. The International Journal of Engineering and Science, 2 (7), 54-59.

Farombi E.O, Adelowo O.A and Ajimoko Y.R. (2007). Biomarkers of oxidative stress and heavy metal levels as an indicator of environmental pollution in African catfish (Clarias

gariepinus) from the Nigeria Ogun River. Int J Environ Res Public Health. 4(2):158-65.

Guyton, A. C., & Hall, J. E. (2019). Textbook of medical physiology. Philadelphia, PA: Saunders; 2006.

Miller, A.M. and Harley, J.P. (1996).Zoology. USA: Wm. C. Brown Publishers

Mishra, S., Sharma, S. and Sharma, R. (2018). Bryophyllum pinnatum: A review of its pharmacological and therapeutic potential. Journal of Pharmacy and Pharmacology, 70(8): 1031-1044.

Olaniyi, K. S., & Amusa, O. A. (2020). Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanying injury in streptozotocin-nicotinamide-induced diabetic rats. Biomedicine & Pharmacotherapy, 128: 110226, 2019.

Ogbonna, A. C., Ademowo, O. G., Obi, F. O. (2019). Premium motor spirit (PMS) exposure induces liver damage in rats. Journal of Environmental and Public Health, 1-8.

Okwu, D. E., and Josiah, C. (2019).Evaluation of the Chemical Composition of Bryophyllum Pinnatum. Journal of Science, 6:30-37.

Oyewopo, A. O., Adedeji, A. L. and Oyeleke, S. B. (2017). Bryophyllum pinnatum extract mitigates premium motor spirit-induced liver damage in rats. Journal of Applied Sciences and Environmental Management, 21(2):257-264.

Sharma, S. and Soni, I. (2016). Impact of petroleum fumes on liver and kidney function of industrial workers. International Journal of Occupational and Environmental Health, 22(3), 246-253.

Vagvala, S.H. and O'Connor, S.D. (2018). Imaging of abnormal liver function tests. Clin Liver Dis (Hoboken).11(5):128-134.