EFFECT OF CAPSICUM ANNUM ON THE SERUM ELECTROLYTE PANEL OF WISTAR ALBINO RATS INDUCED WITH ASPIRIN
Abstract
Peptic ulcer disease remains one of the most prevalent gastrointestinal diseases and has been linked to H. pylori infection and the use of non-steroidal anti-inflammatory drugs. Capsicum annum is known for its anti-inflammatory, antioxidant, antibacterial, nutritional, and medicinal properties. This study aimed to determine the effects of aspirin on antioxidant parameters in male wistar albino rats. Twenty (25) male wistar albino rats were procured and acclimatized for 2 weeks under normal laboratory conditions and were divided into five groups containing five male rats each. Group A (blank control) was neither induced with aspirin nor treated, but was only fed with water and food. Group B (negative control) was induced with 50 mg/kg of aspirin and was not treated. Group C (positive control) was induced with 50 mg/kg of aspirin and was treated with omeprazole. Group D (low-dose Capsicum anuum) was induced with aspirin and treated with 100 mg/kg of C. annum extract, and group E (high-dose control) was induced with aspirin and treated with 400 mg/kg of Capsicum annum ethanoic extract. Ulceration and treatment were administered orally via intubation. After 4 weeks of treatment, ulceration significantly decreased the Na ion level (p > 0.05) in the negative control group (56.60 ±10.40) and increased when treated with both low-dose and high-dose Capsicum annum extract (105.40 ± 12.60, ± 9.86). Changes in other parameters were not significant in low- and high-dose treatments.
Keywords:
Ulcer, Aspirin, Serum, Capsicum annumDownloads
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Copyright (c) 2025 Edoga Cyril Onyekachi, Ezema Christiana Onyinyechi , Offor Amarachukwu Grace
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