THE IMPACT OF VITAMIN C SUPPLEMENTATION ON VANCOMYCIN-INDUCED NEPHROTOXICITY

Abstract

Vancomycin, a glycopeptide antibiotic, is a potent bactericidal agent that hinders bacterial cell wall synthesis. It is commonly prescribed for combating methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive bacterial infections. Despite its effectiveness, the use of vancomycin can lead to nephrotoxicity, necessitating treatment discontinuation and resulting in adverse outcomes for patients. This review examines the clinical implications and management of vancomycin-induced nephrotoxicity, shedding light on its impact on patient morbidity and mortality. Understanding the risk factors, monitoring strategies, and potential interventions for vancomycin-associated nephrotoxicity is crucial in optimizing the therapeutic benefits while minimizing adverse effects. This comprehensive analysis provides valuable insights for healthcare professionals to enhance the safe and effective use of vancomycin in clinical practice