International Research Journal of Medical and Pharmaceutical Sciences (IRJMPS)

MALARIA-INDUCED HAEMOSTATIC CHANGES IN SEMI-URBAN AREAS

Authors

  • Ibrahim Yusuf Adetokunbo Department of Medical Laboratory Science, Achievers University, Owo-Nigeria

Abstract

Malaria persists as a major public health issue in endemic regions, impacting numerous physiological parameters, including haemostasis. This study explores the haemostatic parameters in malaria-infected patients from a semi-urban area within a malaria-endemic region. By analyzing these parameters, the research aims to improve the understanding of malaria's effect on blood clotting mechanisms and identify potential haemostasis-related complications. Blood samples from diagnosed malaria patients were collected and assessed for key haemostatic markers. The results indicate alterations in several haemostatic parameters, suggesting a link between malaria infection and disrupted blood clotting processes. These findings highlight the necessity of monitoring haemostatic parameters in malaria management and lay the groundwork for further research into mitigating haemostasis-related complications in malaria-infected individuals

Keywords:

Malaria, Haemostasis, Blood Clotting, Malaria Complications, Endemic Regions

Published

2024-07-26

DOI:

https://doi.org/10.5281/zenodo.12914144

How to Cite

Ibrahim , Y. A. (2024). MALARIA-INDUCED HAEMOSTATIC CHANGES IN SEMI-URBAN AREAS. International Research Journal of Medical and Pharmaceutical Sciences (IRJMPS), 9(3), 1–10. https://doi.org/10.5281/zenodo.12914144

References

Abro, A.H., Saleh, A.A., Abdou, A.S., Ustadi, A.M., Shuri, M. and Seliem, R.M., 2009. Thrombocytopenia in adults with acute malaria. RMJ, 34(2), pp.170-172.

Adeosun, O.G., Oduola, T., Akanji, B.O., Sunday, A.M., Udoh, S.J. and Bello, I.S., 2007. Biochemical alteration in Nigerian children with acute falciparum malaria. African Journal of Biotechnology, 6(7). pp. 881–885

Alho, R.M., Machado, K.V.A., Val, F.F., Fraiji, N.A., Alexandre, M.A., Melo, G.C., Recht, J., Siqueira, A.M., Monteiro, W.M. and Lacerda, M.V., 2017. Alternative transmission routes in the malaria elimination era: an overview of transfusion-transmitted malaria in the Americas. Malaria journal, 16(1), pp.1-14.

https://doi.org/10.1186/s12936-017-1726-y

Al Karsani, M.S. and Ali, M.S.M., 2009. Haematological Changes In Malaria Infected Blood Stored In Blood Bank Refrigerator (1-6° C). Journal of Science and Technology, 10(1), pp.1-11.

Allain, J. P. (2010). Malaria and transfusion: A neglected subject coming back to the forefront. In Clinical Infectious Diseases 51(10), pp. 1199–1200. https://doi.org/10.1086/656807

Al-Salahy, M., Shnawa, B., Abed, G., Mandour, A. and Al-Ezzi, A., 2016. Parasitaemia and Its Relation to Hematological Parameters and Liver Function among Patients Malaria in Abs, Hajjah, Northwest Yemen. Interdisciplinary Perspectives on Infectious

Diseases, 2016, pp.5954394-5954394. https://doi.org/10.1155/2016/5954394

Biggam, A.G., 1929. Malignant malaria associated with the administration of heroin intravenously. Transactions of The Royal Society of Tropical Medicine and Hygiene, 23(2), pp.147-153. https://doi.org/10.1016/S0035-9203(29)90473-9

Bilal, J.A., Malik, E.E., Al-Nafeesah, A. and Adam, I., 2020. Global prevalence of congenital malaria: A systematic review and meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 252, pp.534-542. https://doi.org/10.1016/j.ejogrb.2020.06.025

Chau, T.T.H., Mai, N.T.H., Phu, N.H., Luxemburger, C., Chuong, L.V., Loc, P.P., Trang, T.T.M., Vinh, H., Cuong, B.M., Waller, D.J. and Sinh, D.X., 2002. Malaria in injection drug abusers in Vietnam. Clinical infectious diseases, 34(10), pp.1317-1322. https://doi.org/10.1086/340053

Cheesbrough, M. 2006. District Laboratory Practice in Tropical countries, part 1, Cambridge Low price Edition. Pp. 248-250. Cambridge University Press

Cohee, L. and Laufer, M., 2018. Tackling malaria transmission in sub-Saharan Africa. The Lancet Global Health, 6(6), pp.e598e599. https://doi.org/10.1016/S2214-109X(18)30197-9

Dace, J. and Lewis, S., 2001. Basic Haematological techniques.

In Practical haematology 9th edition. Edited by Barbara JB,

Mitchell LS, Imelda B. London:, pp 487-490. Churchill Livingstone

Erel, O., Vural, H., Aksoy, N., Aslan, G. and Ulukanligil, M., 2001. Oxidative stress of platelets and thrombocytopenia in patients with vivax malaria. Clinical biochemistry, 34(4), pp.341-344.

Erhabor, O., Abdulrahaman, A. and Erhabor, T., 2020. Effects of malaria parasitaemia on some haemostatic parameters among pregnant women of African descent in Specialist

Hospital Sokoto, Nigeria. Human Antibodies, 28(1), pp.21-28. https://doi.org/10.3233/HAB-190389

Facer CA (1994). Hematological aspects of malaria. In: Infection and hematology. Oxford:, pp. 259-294. Butterworht Heinmann ltd

Franklinos, L.H., Jones, K.E., Redding, D.W. and Abubakar, I., 2019.

The effect of global change on mosquito-borne disease. The Lancet

Infectious Diseases, 19(9), pp.e302-e312.

https://doi.org/10.1016/S1473-3099(19)30161-6

Gupta, P., Guddattu, V. and Saravu, K., 2019. Characterization of platelet count and platelet indices and their potential role to predict severity in malaria. Pathogens and global health, 113(2), pp.8693.https://doi.org/10.1080/20477724.2019.1600855

Horstmann, R.D. and Dietrich, M., 1985. Haemostatic alterations in malaria correlate to parasitaemia. Blut, 51(5), pp.329-335.

Khan, S.J., Khan, F.R., Usman, M. and Zahid, S., 2008. Malaria can lead to Thrombocytopenia. Rawal Medical Journal, 33(2), pp.183185.

Kayode, O.T., Kayode, A.A.A. and Awonuga, O.O., 2011. Status of selected hematological and biochemical parameters in malaria and malaria-typhoid co-infection. Journal of Biological Sciences, 11(5), pp.367-373. https://doi.org/10.3923/jbs.2011.367.373

Lillicrap, D., Key, N., Makris, M. and O’Shaughnessy, D. 2009. Practical Hemostsis and Thrombosis.. Pp. 1-5. Wiley-Blackwell

London School of Hygiene & Tropical Medicine. 2021. The Global Challenge of Vector-Borne Diseases and How to Control Them |

LSHTM. Retrieved June 4, 2021, from

https://www.lshtm.ac.uk/study/courses/short-courses/free-onlinecourses/vector-borne-diseases

Maina, R.N., Walsh, D., Gaddy, C., Hongo, G., Waitumbi, J., Otieno, L., Jones, D. and Ogutu, B.R., 2010. Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malaria journal, 9(3), pp.1-11.

https://doi.org/10.1186/1475-2875-9-S3-S4

Miller, L.H., Baruch, D.I., Marsh, K. and Doumbo, O.K., 2002. The pathogenic basis of malaria. Nature, 415(6872), pp.673-679.

Minard, G., Touche, S., Delavelle, A.C., Bonnet, M., Huguenin, A. and

N’Guyen, Y., 2020. Case Report: Could Artemisinin-Based Combination Therapy Prevent Occupational Malaria following Blood Exposure?. The American Journal of Tropical Medicine and

Hygiene, 104(1), pp.240-242. https://doi.org/10.4269/AJTMH.20-0717

Mohapatra, S., Samantaray, J.C., Arulselvi, S. and Ghosh, A., 2013. Disseminated intravascular coagulation following malaria due to Plasmodium vivax: a thromboelastography-based study. Malaria journal, 12(1), pp.1-4. doi:10.1186/1475-2875-12-336

National Population Commission, 2007: 2006 Population and housing

Census Enumerator’s Manual. Federal Republic of Nigeria, Abuja Nigeria. https://www.nationalpopulation.gov.n

Oladimeji, K.E., Tsoka-Gwegweni, J.M., Ojewole, E. and Yunga, S.T., 2019. Knowledge of malaria prevention among pregnant women and non-pregnant mothers of children aged under 5 years in Ibadan, South West Nigeria. Malaria journal, 18(1), pp.1-12.

https://doi.org/10.1186/s12936-019-2706-1

Olupot-Olupot, P., Eregu, E.I., Naizuli, K., Ikiror, J., Acom, L. and Burgoine, K., 2018. Neonatal and congenital malaria: a case series in malaria endemic eastern Uganda. Malaria journal, 17(1), pp.1-5.. https://doi.org/10.1186/s12936-018-2327-0

Omer, S.A., Adam, I., Noureldien, A., Elhaj, H., Guerrero-Latorre, L., Silgado, A., Sulleiro, E. and Molina, I., 2020. Congenital Malaria in Newborns Delivered to Mothers with Malaria-Infected Placenta in

Blue Nile State, Sudan. Journal of tropical pediatrics, 66(4), pp.428-

. https://doi.org/10.1093/TROPEJ/FMZ083

Osaro, E., Jamilu, M.H., Ahmed, H. and Ezimah, A., 2014. Effect of plasmodium Parasitaemia on some haematological parameters in children living in Sokoto, North Western, Nigeria. International Journal of Clinical Medicine Research, 1(2), pp.57-64. http://www.aascit.org/journal/ijcmr

Owusu-Ofori, A.K., Parry, C. and Bates, I., 2010. Transfusiontransmitted malaria in countries where malaria is endemic: a review of the literature from sub-Saharan Africa. Clinical Infectious Diseases, 51(10), pp.1192-1198. https://doi.org/10.1086/656806

Oyibo, W., Ntadom, G., Uhomoibhi, P., Oresanya, O., Ogbulafor, N., Ajumobi, O., Okoh, F., Maxwell, K., Ezeiru, S., Nwokolo, E. and Amajoh, C., 2021. Geographical and temporal variation in reduction of malaria infection among children under 5 years of age throughout Nigeria. BMJ global health, 6(2), p.e004250. https://doi.org/10.1136/bmjgh-2020-004250

Peprah, S., Ogwang, M.D., Kerchan, P., Reynolds, S.J., Tenge, C.N., Were, P.A., Kuremu, R.T., Wekesa, W.N., Masalu, N., Kawira, E. and Kinyera, T., 2020. Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya. British journal of haematology, 190(5), pp.772-782. https://doi.org/10.1111/bjh.16700

Percário, S., Moreira, D.R., Gomes, B.A., Ferreira, M.E., Gonçalves, A.C.M., Laurindo, P.S., Vilhena, T.C., Dolabela, M.F. and Green, M.D., 2012. Oxidative stress in malaria. International journal of molecular sciences, 13(12), pp.1634616372.

Ramalho-Ortigao, M., & Gubler, D. J. (2020). Human Diseases Associated With Vectors (Arthropods in Disease

Transmission). In Hunter’s Tropical Medicine and Emerging Infectious Diseases pp. 1063–1069. Elsevier.

https://doi.org/10.1016/b978-0-323-55512-8.00147-2

Ramnik S (2009). Medical Laboratory Technology Methods and Interpretations 6th edition, Jaypee Brother Medical Publishers Ltd, New Delhi, pp380-383. Jaypee Brother Medical Publishers Ltd, New Delhi

Rowe, J.A., Claessens, A., Corrigan, R.A. and Arman, M., 2009. Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. Expert Reviews in Molecular Medicine, 11(e16), pp.26-2009.doi:10.1017/S1462399409001082

Sakzabre, D., Asiamah, E.A., Akorsu, E.E., Abaka-Yawson, A., Dika, N.D., Kwasie, D.A., Ativi, E., Tseyiboe, C. and Osei, G.Y., 2020. Haematological Profile of Adults with Malaria Parasitaemia Visiting the Volta Regional Hospital, Ghana. Advances in Hematology, 2020, pp.9369758-9369758. https://doi.org/10.1155/2020/9369758

Sotimehin, S.A., Runsewe-Abiodun, T.I., Oladapo, O.T., Njokanma, O.F. and Olanrewaju, D.M., 2008. Possible risk factors for congenital malaria at a tertiary care hospital in Sagamu, Ogun State, South-West Nigeria. Journal of Tropical Pediatrics, 54(5), pp.313-320.

https://doi.org/10.1093/tropej/fmn016

Squire, D.S., Asmah, R.H., Brown, C.A., Adjei, D.N., ObengNkrumah, N. and Ayeh-Kumi, P.F., 2016. Effect of Plasmodium falciparum malaria parasites on haematological parameters in Ghanaian children. Journal of parasitic diseases, 40(2), pp.303-311. https://doi.org/10.1007/S12639-014-0501-Z

Weir, W., 1997. Two cases of malaria: four messages. Weekly releases (1997–2007), 1(12),

p.1077.https://doi.org/10.2807/esw.01.12.01077-en

Wells, M.B. and Andrew, D.J., 2019. Anopheles salivary gland architecture shapes plasmodium sporozoite availability for transmission. mBio, 10(4), pp.e01238-19. https://doi.org/10.1128/mBio

Wickramasinghe, S.N. and Abdalla, S.H., 2000. Blood and bone marrow changes in malaria. Best Practice & Research Clinical Haematology, 13(2), pp.277-299.

https://doi.org/10.1053/beha.1999.0072

World Health Organization. 2020. Vector-borne diseases. https://www.who.int/news-room/fact-sheets/detail/vector-bornediseases (accessed 4th June 2021)

World Health Organization. (2021). Malaria. 2021. https://www.who.int/news-room/fact-sheets/detail/malaria (accessed 3rd June 2021)

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