EFFECT OF BRYOPHYLLUM PINNATUM EXTRACT ON BLOOD PARAMETERS OF MALE WISTAR ALBINO RATS EXPOSED TO KEROSENE
Abstract
This study investigated the effects of B. pinnatum extract on the haematological parameters of male Wistar albino rats exposed to kerosene fumes. A total of 25 male Wistar rats were divided into five groups. Groups A and B are blank and negative controls, respectively. Groups C, D, and E were exposed to 500 ml of kerosene and treated with 100, 200, and 500 mg/kg B. pinnatum extract, respectively. The results showed significant alterations in haematological parameters due to kerosene exposure, with significant differences (p<0.05) in PCV, RBC, WBC, haemoglobin, lymphocytes, neutrophils, eosinophils, monocytes, and basophils. Bryophyllum pinnatum increased PCV from (26.30 ± 1.00) to (43.45 ± 1.00). The same applies to other parameters, except basophil concentration, which neither kerosene exposure nor Bryophyllum pinnatum affects. However, treatment with B. pinnatum extract showed ameliorative effects, particularly at higher doses, by restoring blood parameters closer to baseline levels. These findings propose that B. pinnatum could serve as a natural remedy for mitigating the toxic haematological effects of environmental pollutants, including kerosene.
Keywords:
white blood cell differentia, Hemoglobin, Packed cell volume, white blood cell, red blood cell, Bryophyllum pinnatumDownloads
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Copyright (c) 2025 Edoga Cyril Onyekachi, Nnamani Chidinma Praise , Offor Amarachukwu Grace
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